CHEK2 and breast cancer: For the moderate-risk homologous recombination repair (HRR) breast cancer genes ATM, BARD1, CHEK2, and NBN, [2, 44] 3.3% (p = 7.2 × 10− 04) of unselected pancreatic cancer cases carried a clearly pathogenic variant, and weighted inclusion of HiP-VUS increased the proportion to 5.1% (p = 2.3 × 10− 08).