Adding other high-risk genes such as TP53, CDKN2A, and STK11 results in 5.1% (95% CI: 3.3–7.2) of pancreatic cancer cases with a sequence variant that would alter medical management of healthy at-risk relatives: i.e. MRI in addition to mammography or early colonoscopy (Fig. 2) [7, 9, 45–47]. This evidence concerns the gene TP53 and familial pancreatic carcinoma.