Using our in vivo system, we previously found the Forkhead box transcription factor Foxf2 to be a canonical Shh target gene that promotes proliferation of the cNCC-derived mesenchyme and is downregulated in the cNCC-derived FNP and MNP mesenchyme during OFC pathogenesis [13]. The gene discussed is FOXF2; the disease is otofaciocervical syndrome 1.