A recent study reported that RUNX1T1 is an inhibitor of brown adipogenesis (associated with a lean and healthy phenotype), which was associated with obesity and suggested that the miRNAs that downregulates this TF could be part of novel therapeutics to increase BAT (brown adipose tissue) in humans [54]. Here, RUNX1T1 is linked to obesity due to melanocortin 4 receptor deficiency.