C57BL/6 mice submitted to FFD for 7 mo or the KCa3.1 null mice, CD-1 mice or CD-1 mice subjected to hepatic ischemia-reperfusion injury exhibited an average serum level of AFP of 65±5 ng/mL (range 54 to 113 ng/mL),below the HCC threshold/cutoff of 136 ng/mL. Here, KCNN4 is linked to hepatocellular carcinoma.