CCN2 and Huntington disease: In addition, CCN2 protein expression is significantly greater inatherosclerotic plaques compared to fibrous plaques, more stable, and may increasemonocyte migration in atherosclerotic lesions, thus contributing toatherogenesis.79 In Caucasian individualsin HD, polymorphism in CCN2 gene was considered a prognostic riskfactor for cardiovascular morbidity and mortality.77