MTHFR and chronic kidney disease: VC is highly prevalent among CKD patients, progressing often over a relatively shortperiod of time, and is a strong predictor of CVD and all-cause mortality in thispopulation.62,63 Thus, studies included in this review,three investigated polymorphisms in genes that could influence VC and, consequently,cardiovascular risk, being: matrix Gla protein (MGP), vitamin K epoxide reductase(VKORC) and 5,10 methylenetetrahydrofolate (MTHFR) (Table 3).