The other is CT replacement at the position of nucleotide161 at exon 6 (C161T).53 Previous studieshave shown that these polymorphisms may play an important role in carotid arteryatherosclerosis in populations characterized by dyslipidemia, diabetes, obesity andCVD.54,55 However, in Chinese HD individuals, thesetwo polymorphisms were associated with significant risk factors for CVD, such asincreased C-reactive protein and carotid intima-media thickness, as well asformation of atheromatous plaques in these arteries, but not to the lipid metabolismand nutrition.9 This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.