The inactivation of this enzyme increases the vitamin'srequirements to values above the one present in the diet, resulting in itsfunctional insufficiency.68 VKORC1 is thegene coding for VKOR, and polymorphisms in this gene were associated with theavailability of vitamin K active for the carboxylation of coagulation factors,particularly resistance to coumarin.69Increased concentrations of coagulation factors associated with these polymorphismsmay be related to vascular events as a consequence of hypercoagulability.70 Here, VKORC1 is linked to thrombophilia.