CDKN2B-AS1 and diabetes mellitus: Finally, individuals homozygous for the risk allele (GG) of the SNP rs10757278 in theANRIL (antisense non-coding RNA) showed a two-fold increased risk of adversecardiovascular event than those with the protective allele (AA or AG), even afteradjustment for other risk factors such as diabetes mellitus. 80 ANRIL is located on chromosome 9p21.3 and isconsidered the genetic factor most strongly associated with atheroscleroticCVD.81 Increased expression of this genespeeds up proliferation, increases adhesion, and decreases apoptosis,81 mechanism related to the pathogenesis ofatherosclerosis.