Homozygoteswith genotype I/I have the lowest levels, and I/D heterozygotes have intermediateplasma levels of this enzyme.59 Thispolymorphism leads to a greater predisposition to the development of CVD, such asmyocardial infarction, stroke and other atherosclerotic disorders.60,61 Indeed, in HD individuals, the ACE genepolymorphism was associated with the development of stroke, and the D allele of thisgene significantly increased the risk of developing left ventricular hypertrophy andperipheral vascular disease. This evidence concerns the gene ACE and Huntington disease.