HLA-C and Huntington disease: The gene encoding RAGE is located on chromosome 6p213 in the major histocompatibility complex (MHC), and comprises 11 exons.Of all the polymorphisms identified in this gene, the -374 T/A variant wasassociated with CVD.22 Several studies haveshown a strong link between the genotype -374A or AA and protection against vasculardisease.23,24 These results were also confirmed inCaucasian individuals in HD, in which the presence of the A allele of thispolymorphism had a protective effect against cerebrovascular accidents.25