In AngII-dependent malignant hypertension in Cyp1a1-Ren2 transgenic rats26, it was demonstrated that HSD, alongwith chronic administration of the AT1R antagonist, attenuates theincreased systolic blood pressure and intra-renal Ang II levels, demonstratingthe importance of AT1R in the local RAAS effect. This evidence concerns the gene CYP1A1 and malignant hypertension.