ARC and Alzheimer disease: Activity‐Regulated Cytoskeleton‐Associated Protein (ARC) [2.97‐fold increase, FDR‐ p = 0.045] is proposed to participate in AD pathogenesis, because ARC is required for activity‐dependent generation of amyloid‐β, and genetic deletion of ARC (−/−) reduces amyloid‐β load in a transgenic mouse model of AD (APPSWE;PS1ΔE9) (Wu et al., 2011).