SHISA8 and Alzheimer disease: However, genes directly or indirectly involved in AD pathology and its modulation (e.g., ARC, DAO, Ebf3, PPP1r17), along with genes that modulate neuronal function and/or behavior (e.g., PMCH, Shisa8, Slc6a5), were identified in the present study, strongly suggesting that Sgo1−/+ haploinsufficiency affects the animal's cognitive functions and/or behavior at later ages.