In fact, we observed at least three pathways for TDP-43 dispersal following motor neuron degeneration after injury: this included diffusion of TDP-43 from the nucleus to the cytoplasm after neuronal swelling, compartmentalised TDP-43 release in discrete quanta, and the breakdown of homeostatic TDP-43 exclusion from the axon. The gene discussed is TARDBP; the disease is Motor neuron atrophy.