KLF6 and metabolic dysfunction-associated steatohepatitis: A single nucleotide polymorphism (KLF6–IVS1-27G>A, rs3750861) that promotes alternative splicing of KLF6 into the dominant-negative variant was shown to negatively associate with the level of NASH-related fibrosis (42), supporting the notion that full-length KLF6 promotes fibrosis.