In one study, from data in 105 patients with GI malignancies, some with HCC, overall concordance rates of 96, 94, 95, and 91%, respectively, were found between ctDNA and tissue biopsy in the four most common alterations (KRAS amplification, MYC amplification, KRAS G12V, and EGFR amplification) (27). Here, KRAS is linked to hepatocellular carcinoma.