Remarkably, using low doses of PI3K inhibitors may regulate tortuous and immature tumor vessels into the regularity of endothelial cell structure, pericyte coverage and tight junctions, and the persistent modulation of vasculature improves tumor hypoxia and vascular perfusion, with reduced metastatic nodules in distant organs (Fokas et al., 2012; Kim et al., 2017; Qayum et al., 2012; Qayum et al., 2009). Here, PIK3CA is linked to neoplasm.