In contrast, selective blockade of PI3Kγ polarizes tumor-associated macrophages to restore CD8+ T cell-mediated cytotoxic activity, thus promoting tumor regression and extending survival time in various mouse cancer models (De Henau et al., 2016; Foubert, Kaneda & Varner, 2017; Kaneda et al., 2016a, 2016b). This evidence concerns the gene CD8A and neoplasm.