BDH1 and breast carcinoma: Interestingly, we detected variable levels of mRNA expression for key enzymes of ketolysis, namely 3-hydroxybutyrate dehydrogenase 1 (BDH1), succinyl-CoA transferase (SCOT), and acetyl-CoA-acetyltransferase (ACAT), in the seven human breast cancer cell lines (Fig. 3b).