While preclinical data have shown that AcAc promotes proliferation of BRAF-V600-positive melanoma cells [73], it is interesting that in a pilot study [13] it was a patient with BRAF V600E-positive/BRAF-inhibitor-resistant melanoma who responded favorably to a KD; this highlights the limitations of translating preclinical study results to humans. This evidence concerns the gene BRAF and melanoma.