Tumorigenesis and CRC metastasis are hypothesized to occur by different mechanisms involving cancer stems cells (CSC), the overexpression of cyclooxygenase-2 (COX-2) and epidermal growth factor (EGFR), and other downstream effects in the early phases of CRC [2–4]; Aspirin is postulated to play its role by modifying these epigenetic events, especially among patients with mutated-PIK3CA [4]. The gene discussed is PTGS2; the disease is cancer.