It was interesting to read the article Aspirin inhibited the metastasis of colon cancer cells by inhibiting the expression of toll-like receptor 4 published by Ying et al. Several studies have explored the mechanism of Aspirin in preventing colorectal cancer (CRC) and also that of metastases in CRC [1–4] but this study was noteworthy in that it explored the mechanism of Aspirin in preventing liver metastases in CRC. The gene discussed is TLR4; the disease is colonic neoplasm.