Although arguably premature as an overview, the progress of LIF-NP in nanomedicine is well underway and future major indications include the neurodegenerative diseases where LIF may reduce inflammatory pathogenesis and be prosurvival for neurons, for example in Parkinson's and Alzheimer's Diseases; also the retinopathies, where LIF's neurogenic and neuroprotective properties may reduce loss of vision by supporting the retinal pigment epithelium of the eye. This evidence concerns the gene LIF and Alzheimer disease.