Our in vivo findings (Figure 7) correlated with those found in vitro (Figures 4–6) and show that OT-I T-cells pre-cultured on substrate-immobilized CCL21 + ICAM1, suppressed tumor growth to a significantly greater extent than those pre-cultured on an uncoated substrate (Figures 7A,B). The gene discussed is ICAM1; the disease is neoplasm.