S100A8/A9 could be used as a biomarker in many inflammatory diseases, such as juvenile RA (109), inflammatory arthritis disease (110), skin stresses (111), transplantation (112), inflammatory bowel disease (IBD) (113), islet inflammatory response, severe forms of glomerulonephritis (68), cystic fibrosis (114), periodontitis, autoimmune synovitis (115), inflammation of the uterine cervix (116), peritonitis (117), microcirculatory defects in diabetic nephropathy (118), infections (119, 120), CVDs (121, 122), and autoimmune diseases such as juvenile dermatomyositis (123). This evidence concerns the gene S100A8 and periodontitis.