CYP17A1 and Insulin resistance: Genetic association studies have revealed that the CYP17A1 gene plays an important role in various pathological conditions, such as visceral and subcutaneous fat accumulation (13), coronary artery disease (CAD) (14), hypertension (12), prostate cancer (15), insulin resistance, and polycystic ovary syndrome (16), which are often related to T2DM.