Studies have shown that mutations in certain CYP17A1 sites could reduce the expression of P450c17, which may result in impaired androgen, estrogen, and cortisol hormone synthesis, while producing excessive mineralocorticoids, which may cause hypertension, hypokalemia, pseudohermaphroditism, and delayed sexual maturation (11, 12). The gene discussed is CYP17A1; the disease is Hypertension.