FGF23 and chronic kidney disease: This model may also help to explain the hungry bone syndrome in CKD patients after parathyroidectomy or kidney transplantation, because the decline in bony FGF23 secretion postsurgery will lift the FGF23-induced suppression of TNAP, leading to increased mineralization of previously unmineralized osteoid, and, hence, increased flux of calcium and phosphate into bone.