However, in contrast to WT mice, osteoclast numbers and mineralization lag time in CKD Fgf23/VDR mice were not significantly different from Sham Fgf23/VDR mice, and showed, together with bone formation rate, only non-significant trends toward higher levels in CKD vs. Sham mice (Figure 5C). Here, FGF23 is linked to chronic kidney disease.