In the current study, we presented a comprehensive meta-analysis for 12 polymorphisms in four VEGF/hypoxia/angiogenesis pathway genes (VEGF, HIF1α, eNOS, and HRAS) including 96 case-control studies to examine the precise associations between these polymorphisms and risk of urogenital neoplasms. Here, HIF1A is linked to urogenital neoplasm.