SOS1 and Noonan syndrome: Interactions of both NF1 and SOS1 genes with NRAS (homolog of KRAS) gene in MAPK pathway have been previously associated with Noonan syndrome (Baralle et al., 2003; Longoni et al., 2010), a multisystem developmental disorder that includes perturbed neurodevelopment (Noonan, 2005; Roelofs et al., 2016), and RASA2 mutations have also been reported in individuals with Noonan syndrome (Chen et al., 2014).