While Noonan syndrome has a large array of physiological abnormalities, and that we did not explicitly examine interactions with NRAS (having collapsed the corresponding, RAS family node of the MAPK pathway to KRAS), this suggests that changes in how NF1 and SOS1 interact with the RAS genes contribute towards neurodevelopmental disorders (like SCZ and Noonan syndrome), possibly through altered coordination of signaling to the RAS/RAF component of the MAPK pathway. Here, SOS1 is linked to neurodevelopmental disorder.