While the N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) and interleukin-6 (IL-6) levels were significantly higher, the levels of alanine aminotransferase (ALT), total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol, as well as leukocytes, and platelets were significantly lower in patients with worsening of CHF compared to de novo AHF patients (Table 2). This evidence concerns the gene NPPB and congestive heart failure.