TP53 and cancer: Accumulating evidence has demonstrated that the well-known five modes of AS contributed to the onset and ongoing of tumors through different mechanisms including tumor invasion and metastasis50, epithelial to mesenchymal evasion, cancerous splicing of molecular markers (e.g., CD44 for cancer stem cells51) or classical tumor suppressors (e.g., BRCA and p53 for key cancerous pathways52).