This hypothesis is ably supported by the observations that adiponectin, a natural AMPK activator, inhibits hypertrophic signaling in the myocardium through activation of AMPK signaling and adiponectin have been use in the treatment of hypertrophic cardiomyopathy associated with diabetes and other obesity-related27. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.