TIMP2 and cancer: Given the fact that TIMP2 was found to inhibit metastasis and angiogenesis in vitro on one hand, but on the other hand high TIMP2 correlates with malignant phenotype and unfavorable prognosis of cancer patients in lots of clinical assays44–47, our current study also encounters with the existing unsolved TIMP2 paradox and serves as another evidence for the paradoxical phenomenon.