For instance, mutations in parkin (PARK2), DJ-1 (PARK7), and PINK1 (PARK6) are associated with recessive early-onset forms of PD, whereas mutations in α-synuclein (PARK1–4) and LRRK2 (PARK8) are responsible for the dominant forms of familial PD. The gene discussed is PRKN; the disease is Parkinson disease.