ADCYAP1R1 and Huntington disease: Since CALN1 is a human brain-specific gene, whereas MGAT4C is normally expressed in mesodermal tissues like the kidney and ADCYAP1R1 encodes the receptor for peptide signals in response to stress in the brain45–47, we reasoned that miR-192 may promote HD via repressing genes normally expressed in the other two germ layer-derived lineages.