ESR1 and neoplasm: Similar to our previous study21, hsa-miR-7 (split at the median expression level) remained an independent biomarker for poor prognosis among ER-positive patients after correcting for the traditional prognostic factors: age, menopausal status, tumour size, grade, ESR1, PGR and ERBB2 status (HR = 1.53, 95% CI 1.02–2.31, P = 0.04).