In a comparison of elephant cells (two active p53 alleles and 19 p53p), normal human cells (two active p53 alleles), and cells from patients with Li Fraumeni syndrome (one active p53 allele), Abegglen et al. (2015) observed that the induction of apoptosis in response to DNA damage in elephant cells (14.64%; 95% CI, 10.91–18.37%; P < 0.001) was twofold higher than in normal human cells (7.17%; 95% CI, 5.91–8.44%; P < 0.001) and five-fold higher than in cells from patients with Li Fraumeni syndrome (2.71%; 95% CI, 1.93–3.48%). This evidence concerns the gene TP53 and Li-Fraumeni syndrome.