JDP2 and cancer: The role of JDP2 in cancer is controversial because it can partially transform chicken embryonic fibroblasts and accelerate hepatocellular carcinoma in mice, yet it has a tumor-suppressor role in human prostate cancer, features that may relate to its ability to both activate and repress AP-1 target sites, depending on the cellular context and bZIP binding partner (Blazek et al., 2003; Heinrich et al., 2004; Bitton-Worms et al., 2010).