As shown in Fig. 6 C, mcl1a expression was approximately twofold higher in Tg(rag2:jdp2) compared with Tg(rag2:Myc) tumor cells or normal thymocytes (mean expression, 641 vs. 315 and 356 reads per kilobase of exon per million fragments mapped, P = 0.003 and P = 0.01, respectively Fig. 6 C), consistent with our findings of direct regulation of MCL1 by JDP2 in human cells. This evidence concerns the gene MYC and neoplasm.