Notably, Jdp2, encoding a bZIP protein without a reported role in human T-ALL, was the third most frequently retrovirally targeted gene, with the majority of insertions occurring on a CD2-Myc/Runx2 genetic background, suggesting that Jdp2 likely collaborates with these genes in transformation (Stewart et al., 2007). This evidence concerns the gene CD2 and acute lymphoblastic leukemia.