MYC and acute lymphoblastic leukemia: jdp2 thus represents one of only a few select oncogenes (including Myc, Notch, and Myr-AKT) capable of initiating T-ALL in the zebrafish; the long disease latency and incomplete penetrance in our model suggests that as-yet undiscovered secondary mutations are likely to be involved in transformation (Langenau et al., 2003; Gutierrez et al., 2011; Blackburn et al., 2012, 2014).