A pertinent example of this phenomenon in humans can be found in the development of T-ALL in severe combined immunodeficiency patients who received retrovirally transduced, gene-corrected autologous hematopoietic stem cells, where the viral LTR integrated into the vicinity of the LMO2 gene (Hacein-Bey-Abina et al., 2003, 2008; Howe et al., 2008). Here, LMO2 is linked to immunodeficiency disease.