Inducing Paneth cell disorder by knocking out the Ogt gene specifically only in Defa6‐expressing cells or transplanting fecal microbiota from Vil‐Ogt KO mice into antibiotic‐treated wild‐type mice did not cause intestinal inflammation, again supporting the multi‐hit model of IBD (Maloy & Powrie, 2011). The gene discussed is DEFA6; the disease is inflammatory bowel disease.