We used KC mice expressing the mutation of Kras (KrasG12D) in pancreatic progenitor cells and progressing from a healthy condition to different grades of PanIN (PanIN‐1A–1B–2–3) (Hingorani et al, 2003; Cappello et al, 2013) and KPC mice, carrying KrasG12D/+ and p53R172H/+ mutations and developing PanINs that ultimately progresses to overt carcinoma (Hingorani et al, 2005) to study the importance of the selected biomarkers during PDAC induction. This evidence concerns the gene GDI1 and carcinoma.