Molecules in clusters 3, 4, and 6 (TIMP1, sICAM1, MMP7, PICP, PLG, TSP2, IGFBP2, FN, PINP, CCN1, CCN2, Col4) were further analyzed in a larger independent cohort of PDAC patients (n = 131), pancreatitis patients (n = 30), and sex‐matched healthy individuals (n = 131) (cohort no. 2 in Table 1). Here, CCN1 is linked to pancreatitis.