The significantly (p < 0.01) increased expression of IL-6 and IL-8 upon anoxic culture and over time in the absence of HIF1 is particularly relevant since IL-6/IL-8 expression is linked to enhanced cell growth and survival, as well as neutrophil chemotaxis and risk for metastasis in prostate, lung, liver, breast and colon cancers [2, 4, 7–9]. Here, CXCL8 is linked to colonic neoplasm.