PRKN and colorectal cancer: For instance, analysis of the datasets from cBioportal (http://www.cbioportal.org) [23] indicates that the Parkin gene is mutated in < 1% of breast cancer, 2–5% of colorectal cancer, ~ 5% of lung squamous cell carcinoma, and ~ 5% of gastric cancer [22, 24] (Fig. 1).