Silencing of TSG-6 in the administered MSCs resulted in loss of therapeutic activity, whereas, administration of exogenous TSG-6 resulted in replication of therapeutic activity, thus showing that the reduction in TSG-6 in EXO-injected BPD mice show improvement in the inflammatory status of the BPD mice. This evidence concerns the gene TNFAIP6 and bronchopulmonary dysplasia.