ACE and diabetes mellitus: The association between CYP3A4 activity expressed as quinine/3-OH-quinine and hsCRP showed a trend to be significant (β = 0.44; p = 0.05) in a multivariate analysis after full adjustment for age, gender, diabetes mellitus, dialysis vintage, PTH, orosomucoid and medication with angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), beta-blockers or statins (Table 4).