PIK3CA and neoplasm: For instance, we found that DNAs, regardless as to whether they are from the same (KRAS mutations at codons 12/13) or different (PIK3CA and FBXW7 mutations) genomic regions, are all more efficiently released from LoVo than LS174T cells, whereas the reverse occurs when these tumor cells are grown as xenotransplants, e.g. LS174T ctDNAs are much more abundant in blood.