Two different studies from the same group have recently shown the relevance of arachidonate 5-lipoxygenase (Alox5) [105] and arachidonate 15-lipoxygenase (Alox15) [106] genes for the survival of CML leukaemia stem cells (LSC). Here, ALOX5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.