Apolipoproteins have been reported involving with the pathology of PDR [34, 35], here we identified a total of 6 apolipoproteins, 5 were the first time to be found related to PDR while the remaining one, apolipoprotein A-IV (APOA4) was found reduced in the PDR patients compared with the macular hole patients [36] which had conflicts with our result. This evidence concerns the gene APOA4 and macular holes.