2 of the 4 top significant pathways in DAVID Biocarta Pathway Analysis were asthma-related: “Inactivation of GSK3 by AKT causes accumulation of b-catenin in alveolar macrophages” (FDR p-value 1.7 × 10− 2) and “NF-κβ signaling pathway” (FDR p-value 8.0 × 10− 2) (Additional file 1: e-Table S3). This evidence concerns the gene AKT1 and asthma.