Generally, a more in-depth understanding of the trends of PAC can play role in assessing and investigating these risk agents, for instance, although Risch et al found that H.Pylori CagA Strain type might increase the incidence of PC, other researchers like Schulte et al in their meta-analysis concluded that there was no overall relationship between H. Pylori and pancreatic cancer [25, 26]. This evidence concerns the gene S100A8 and pachyonychia congenita.