TP53 and cancer: Over the last decade, the description of splice variants of the TP53 gene has dynamically reformed the p53 field, and p53 isoforms have emerged as possible active contributors in cancer formation and progression [30] We have previously described that p53β and p53γ protein expression correlates positively with overall survival, chemotherapy response and mutational markers for survival in the aggressive blood cancer AML [24] Leukemia in general has a low occurrence of TP53 mutations.