For the carboxy-terminal (C-terminal) altered variants p53β and p53γ and the amino-terminally (N-terminally) truncated isoforms Δ40p53 and Δ133p53, mRNA expression levels have been shown to be associated with tumor characteristics and aggressiveness in other p53-disrupted malignancies, such as breast cancer and epithelial ovarian carcinoma among others [11, 15–23]. Here, TP53 is linked to breast carcinoma.