CDH1 and breast ductal adenocarcinoma: For example, a set comprising genes downregulated in ductal carcinoma vs normal ductal breast cells identified by laser microdissection and microarray analysis [34] and another set of genes that were downregulated in HMLE cells (immortalized nontransformed mammary epithelial) cells after loss of function of E-cadherin (CDH1) achieved by RNAi knockdown or by expression of a dominant-negative form [35].