In our study, the periodic expression of genes in the BMP signalling pathway, including TGFB1 and TGFBR3, and the high expression of Wnt signalling proteins, including WNT2, WNT11, WNT16, and LEF1, indicated the conservation of the regulatory mechanism during HF growth. The gene discussed is TGFBR3; the disease is hydrops fetalis.