MAP3K1 and infection: Thus, on day 4 of infection, TbTOR4 RNAi in the parental cell line generated 38.4±7.6% PAD1+ve cells, whereas TbTOR4 RNAi in the MEKK null mutant at the same time point, few (11.2±2.2%) cells were PAD1 +ve (Fig 8C).