ESR1 and breast cancer: BBP, DBP, and DEHP (at concentrations of 10 nM and 100 nM) combined without (Fig 3B) and with (Fig 3C) E2 (10 nM), just like E2 (10 nM), notably induced the expression of ER α phosphorylation in MCF-10A cells, which were co-cultured with fibroblasts from ER(+) primary breast cancers.