MECOM and acute myeloid leukemia: In endogenously EVI1-expressing SB1690CB AML cells, the highly significant increase in the degree of co-localization with CtBP1 in the presence of genotoxic stress was confirmed with cells with increases of 18.7% ± 3.9 SEM) after H2O2 treatment, and 24.9% ± 4.8 SEM after radiation (n = 3, P < 0.01) (Figure 6A, lower panel, and C).