S100A8 and chronic atrophic gastritis: Chow et al and Vaezi et al hypothesize that this phenomenon might be caused by the CagA‐positive sting's increased virulence toward gastric mucosa and results in a multifocal atrophic gastritis that also involves the destruction of gastric parietal cells, which further impairs acid secretion (more severely as compared to the CagA‐negative subgroup).