However, HIF2α is also a potent inducer of glucose transporter-1 (GLUT-1) (18, 19) and of enolase 2 (ENO2) (28) in ccRCC (Figure 2), which also anticipates an increased rate of glycolysis in cells expressing only HIF2α. Here, EPAS1 is linked to nonpapillary renal cell carcinoma.