For in vivo fluorescence imaging, we incorporated the NIR dye cypate into bt‐BRNPs, yielding Cyp@bt‐BRNPs.16 Cyp@bt‐BRNPs or Cyp@BRNPs were intravenously injected into tumor‐bearing mice (n = 3/group) and whole‐body fluorescence images were taken 12 h after injection. Here, PPIG is linked to neoplasm.