Because of this NF-kB signaling is often a central mediator of the immune and inflammatory response; its activation represents the common endpoint of a series of signal transduction events initiated by a vast array of stimuli related to many biological processes such as apoptosis, cell growth, differentiation, innate-immunity, inflammation, tumor cell growth and the presence of ROS generated by neurotoxic metals in the environment [59,60]. The gene discussed is NFKB1; the disease is neoplasm.